Role of Lysosomes in Lipid Metabolism
© 2016 John Wiley & Sons, Inc. All rights reserved. Many of the acid hydrolases in late endosomes and lysosomes (LE/Ly) participate in the breakdown of lipids. Lipids are delivered to lysosomes by endocytic uptake of lipoproteins, as components of the lipid bilayer involved in vesicle transport, by autophagy, and by cytoplasmic lipid transport proteins. Many of the important pathways of lysosomal lipid metabolism have been elucidated by analysis of the metabolic defects in inherited lysosomal storage disorders. Basic biochemical and genetic studies of cells from these patients have revealed surprisingly complex and interrelated mechanisms for lipid breakdown. Restricting lipid hydrolysis mainly to these internal membranes helps to preserve the integrity of the limiting membrane. In recent years, it has become apparent that autophagy plays an important role in the turnover of lipids in lipid droplets. This means that lysosomal turnover is important in the digestion of cholesteryl esters and triacylglycerides in the core of the droplets.
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