Identification of Functional and Expression Polymorphisms Associated With Risk for Antineutrophil Cytoplasmic Autoantibody–Associated Vasculitis Academic Article uri icon

Overview

MeSH Major

  • Granulomatosis with Polyangiitis
  • HLA-DP beta-Chains
  • Microscopic Polyangiitis
  • Myeloblastin
  • Protein Tyrosine Phosphatase, Non-Receptor Type 22
  • T-Lymphocytes
  • alpha 1-Antitrypsin

abstract

  • This study reveals the association of susceptibility to GPA and MPA with functional gene variants that explain much of the genetic etiology of AAV, could influence and possibly be predictors of the clinical presentation, and appear to alter immune cell proteins and responses likely to be key factors in the pathogenesis of AAV.

authors

publication date

  • May 2017

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC5434905

Digital Object Identifier (DOI)

  • 10.1002/art.40034

PubMed ID

  • 28029757

Additional Document Info

start page

  • 1054

end page

  • 1066

volume

  • 69

number

  • 5