Autophagy, fitness and longevity Review uri icon

Overview

MeSH Major

  • Autophagy
  • Health
  • Longevity

abstract

  • Autophagy is a key mechanism for the maintenance of intracellular and organismal homeostasis. Accordingly, defects in core components of the autophagic machinery are etiologically associated with a variety of human pathologies, including infectious disorders, cardiovascular diseases, neurodegenerative conditions, and cancer. Intriguingly, several maneuvers that increase the lifespan of model organisms in the laboratory, like caloric restriction, do so in an autophagy-dependent manner. Here, we briefly discuss the intimate relationship between the autophagic preservation of intracellular and organismal fitness and healthy aging.

publication date

  • March 2017

Research

keywords

  • Review

Identity

Language

  • fre

Digital Object Identifier (DOI)

  • 10.1051/medsci/20173303010

PubMed ID

  • 28367810

Additional Document Info

start page

  • 246

end page

  • 251

volume

  • 33

number

  • 3