Bromodomain protein 4 discriminates tissue-specific super-enhancers containing disease-specific susceptibility loci in prostate and breast cancer Academic Article uri icon

Overview

MeSH Major

  • Breast Neoplasms
  • Enhancer Elements, Genetic
  • Gene Expression Regulation, Neoplastic
  • Genetic Predisposition to Disease
  • Nuclear Proteins
  • Prostatic Neoplasms
  • Quantitative Trait Loci
  • Transcription Factors

abstract

  • This is the first study to evaluate the enrichment of epigenetic readers in genome-wide associations studies for SNPs within enhancers, and provides a powerful tool for enriching and prioritizing PC and BC genetic risk loci. Our study represents a proof of principle applicable to other diseases and traits that can be used to redefine molecular mechanisms of human phenotypic variation.

authors

publication date

  • March 31, 2017

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC5374680

Digital Object Identifier (DOI)

  • 10.1186/s12864-017-3620-y

PubMed ID

  • 28359301

Additional Document Info

start page

  • 270

volume

  • 18

number

  • 1