Pre-metastatic niches: organ-specific homes for metastases Review uri icon

Overview

MeSH Major

  • Neoplasm Metastasis
  • Neoplasms

abstract

  • It is well established that organs of future metastasis are not passive receivers of circulating tumour cells, but are instead selectively and actively modified by the primary tumour before metastatic spread has even occurred. Sowing the 'seeds' of metastasis requires the action of tumour-secreted factors and tumour-shed extracellular vesicles that enable the 'soil' at distant metastatic sites to encourage the outgrowth of incoming cancer cells. In this Review, we summarize the main processes and new mechanisms involved in the formation of the pre-metastatic niche.

publication date

  • March 17, 2017

Research

keywords

  • Review

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1038/nrc.2017.6

PubMed ID

  • 28303905

Additional Document Info