Dangerous Liaisons: Deviant Endothelium NOTCHes toward Tumor Metastasis Article uri icon

Overview

MeSH Major

  • Cell Line, Tumor
  • Endothelium

abstract

  • In this issue of Cancer Cell, Wieland et al. uncover a feedback loop in which tumor cells, by augmenting Notch signaling, provoke a senescent and pro-inflammatory state in endothelial cells, promoting neutrophil infiltration, tumor cell adhesion, and metastasis. Interfering with this Notch-dependent crosstalk may be a therapeutic approach to block metastasis.

publication date

  • March 13, 2017

Research

keywords

  • Article

Identity

Digital Object Identifier (DOI)

  • 10.1016/j.ccell.2017.02.016

Additional Document Info

start page

  • 301

end page

  • 303

volume

  • 31

number

  • 3