Neuronal Death After Hemorrhagic Stroke In Vitro and In Vivo Shares Features of Ferroptosis and Necroptosis Academic Article uri icon

Overview

MeSH Major

  • Apoptosis
  • Cerebral Hemorrhage
  • Hemin
  • Hemoglobins
  • Necrosis
  • Neurons

abstract

  • Experimental intracerebral hemorrhage shares features of ferroptotic and necroptotic cell death, but not caspase-dependent apoptosis or autophagy. We propose that ferroptosis or necroptotic signaling induced by lysed blood is sufficient to reach a threshold of death that leads to neuronal necrosis and that inhibition of either of these pathways can bring cells below that threshold to survival.

publication date

  • March 2017

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC5613764

Digital Object Identifier (DOI)

  • 10.1161/STROKEAHA.116.015609

PubMed ID

  • 28250197

Additional Document Info