Native-like Env trimers as a platform for HIV-1 vaccine design Review uri icon

Overview

MeSH Major

  • AIDS Vaccines
  • HIV Antigens
  • HIV Infections
  • HIV-1
  • Viral Envelope Proteins

abstract

  • We describe the development and potential use of various designs of recombinant HIV-1 envelope glycoprotein trimers that mimic the structure of the virion-associated spike, which is the target for neutralizing antibodies. The goal of trimer development programs is to induce broadly neutralizing antibodies with the potential to intervene against multiple circulating HIV-1 strains. Among the topics we address are the designs of various constructs; how native-like trimers can be produced and purified; the properties of such trimers in vitro and their immunogenicity in various animals; and the immunization strategies that may lead to the eventual elicitation of broadly neutralizing antibodies. In summary, native-like trimers are a now a platform for structure- and immunology-based design improvements that could eventually yield immunogens of practical value for solving the long-standing HIV-1 vaccine problem.

publication date

  • January 2017

Research

keywords

  • Review

Identity

Language

  • eng

PubMed Central ID

  • PMC5299501

Digital Object Identifier (DOI)

  • 10.1111/imr.12481

PubMed ID

  • 28133806

Additional Document Info

start page

  • 161

end page

  • 182

volume

  • 275

number

  • 1