Patient-level DNA damage and repair pathway profiles and prognosis after prostatectomy for high-risk prostate cancer Academic Article uri icon

Overview

MeSH Major

  • Biomarkers, Tumor
  • DNA Damage
  • DNA Repair
  • Prostatic Neoplasms

abstract

  • DNA damage and repair pathway profiling revealed patient-level variations and the DDR pathways are rarely affected by mutation. A DDR pathway signature showed strong prognostic performance with the long-term outcomes of metastasis-free and overall survival that may be useful for risk stratification of high-risk prostate cancer patients.

publication date

  • April 2016

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC5469505

Digital Object Identifier (DOI)

  • 10.1001/jamaoncol.2015.4955

PubMed ID

  • 26746117

Additional Document Info

start page

  • 471

end page

  • 80

volume

  • 2

number

  • 4