Selective Mineralization of Tough Hydrogel Lumens for Simulating Arterial Plaque Academic Article uri icon

Overview

MeSH Major

  • Cornea
  • Diabetes Mellitus, Type 1
  • Diabetes Mellitus, Type 2
  • Diabetic Neuropathies
  • Microscopy, Confocal

abstract

  • © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, WeinheimThis paper demonstrates progress of fabricating artificial arteries (phantoms) that mimic plaque buildup. Hydrogel lumens are molded using tough polyacrylamide with regions selectively mineralized with calcium phosphate. By tuning the degree of mineralization such as calcium concentration ([Ca2+], 0.4–2 M), and crystallization time (tc, 1–4 weeks), the authors control the extent of lumen occlusion. These occluded lumens significantly reduce pressure (ΔP ≈ 7.79 kPa) during fluid flow compared to the non-calcified lumens (ΔP ≈ 1.24 kPa). Additionally, image, chemical analysis, and compressive mechanical tests are performed to determine the effect of synthesis conditions on the composite's mechanical properties. For comparison to real arteries, the authors also present dynamic mechanical analysis of human aortic tissue.

publication date

  • January 2017

Research

keywords

  • Academic Article

Identity

Digital Object Identifier (DOI)

  • 10.1002/adem.201600591

Additional Document Info

volume

  • 19

number

  • 1