The effect of fenofibrate on expression of genes involved in fatty acids beta-oxidation & associated free-radical processes Academic Article uri icon

Overview

MeSH Major

  • Fatty Acids
  • Fenofibrate
  • Hypolipidemic Agents
  • Reactive Oxygen Species

abstract

  • Fenofibrat – sinteticheskiĭ ligand aktiviruiushchikh proliferatsiiu peroksisom retseptorov podtipa al'fa (PPARa), kotoryĭ ispol'zuetsia dlia lecheniia shirokogo spektra metabolicheskikh zabolevaniĭ, takikh kak gipertriglitseridemii, dislipidemii, diabety, razlichnogo roda neĭrodegenerativnye zabolevaniia. Nami issledovano vliianie fenofibrata na b-okislenie zhirnykh kislot i sviazannye s nim svobodnoradikal'nye protsessy. Naibolee éffektivnaia kontsentratsiia fenofibrata (0,3%), dobavlennaia v korm, privodila k znachitel'nomu snizheniiu massy tela u mysheĭ. Dannye, poluchennye metodom kolichestvennogo PTsR, svidetel'stvuiut ob uvelichenii ékspressii genov pecheni, kodiruiushchikh fermenty b-okisleniia zhirnykh kislot, protekaiushchego kak v peroksisomakh, tak i v mitokhondriiakh. Usilenie okislitel'nykh protsessov vdvoe uvelichivaet skorost' produktsii aktivnykh form kisloroda (AFK), chto podtverzhdaetsia opredeleniem urovnia soderzhaniia produktov perekisnogo okisleniia lipidov (POL) v pecheni. Pri étom mitokhondrial'nye antioksidantnye sistemy bolee chuvstvitel'ny k povysheniiu produktsii AFK, chem peroksisomnye i tsitoplazmaticheskie antioksidantnye sistemy. Ob étom svidetel'stvuiut uvelichenie ékspressii genov SOD2 i PRDX3 i otsutstvie izmeneniĭ v ékspressii genov CAT1, SOD1, PRDX5.

publication date

  • January 2016

Research

keywords

  • Academic Article

Identity

Language

  • rus

Digital Object Identifier (DOI)

  • 10.18097/PBMC20166204426

PubMed ID

  • 27562996

Additional Document Info

start page

  • 426

end page

  • 30

volume

  • 62

number

  • 4