Relationship between clinical parameters and brain structure in sporadic amyotrophic lateral sclerosis patients according to onset type: A voxel-based morphometric study Academic Article uri icon

Overview

MeSH Major

  • Amyotrophic Lateral Sclerosis
  • Brain

abstract

  • Sporadic ALS subtypes show different patterns of brain atrophy. Neural networks related to limb and bulbar motor functions in each ALS subtype may underlie their distinct patterns of cerebral atrophy. That is, more extensive cortical and subcortical atrophy is correlated with greater ALSFRS-R severity and shorter disease duration in the bulbar-onset subtype and may explain the poor prognosis of these patients.

publication date

  • January 2017

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC5240978

Digital Object Identifier (DOI)

  • 10.1371/journal.pone.0168424

PubMed ID

  • 28095425

Additional Document Info

start page

  • e0168424

volume

  • 12

number

  • 1