Early recovery of T-cell function predicts improved survival after T-cell depleted allogeneic transplant Academic Article uri icon

Overview

MeSH Major

  • Interleukins
  • Regeneration
  • Thymocytes
  • Thymus Gland

abstract

  • Infection, relapse, and GVHD can complicate allogeneic hematopoietic stem cell transplantation (allo-HSCT). Although the effect of poor immune recovery on infection risk is well-established, there are limited data on the effect of immune reconstitution on relapse and survival, especially following T-cell depletion (TCD). To characterize the pattern of immune reconstitution in the first year after transplant and its effects on survival and relapse, we performed a retrospective study in 375 recipients of a myeloablative TCD allo-HSCT for hematologic malignancies. We noted that different subsets recover sequentially, CD8 + T cells first, followed by total CD4 + and naïve CD4 + T cells, indicating thymic recovery during the first year after HSCT. In the multivariate model, a fully HLA-matched donor and recovery of T-cell function, assessed by PHA response at 6 months, were the only factors independently associated with OS and EFS. In conclusion, T-cell recovery is an important predictor of outcome after TCD allo-HSCT.

publication date

  • August 3, 2017

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC5454777

Digital Object Identifier (DOI)

  • 10.1080/10428194.2016.1265113

PubMed ID

  • 28073320

Additional Document Info

start page

  • 1859

end page

  • 1871

volume

  • 58

number

  • 8