Intracardiac Low-grade Sarcoma Following Treatment for Ewing Sarcoma Academic Article uri icon

Overview

MeSH Major

  • Biomarkers, Tumor
  • Bone Neoplasms
  • Osteosarcoma
  • Piperazines
  • Protein Kinase Inhibitors
  • Pyrimidines
  • Receptor, Platelet-Derived Growth Factor alpha
  • Receptor, Platelet-Derived Growth Factor beta

abstract

  • A 16-year-old male was diagnosed with Ewing sarcoma of the ribcage with pulmonary metastases. Six months after completion of scheduled therapy, he was found to have a new intracardiac mass, presumed recurrent Ewing sarcoma. EWSR1 fusion was not detected by droplet digital polymerase chain reaction from blood plasma. After no improvement with salvage chemotherapy, he underwent surgical resection that identified a low-grade spindle cell sarcoma. Despite the near-synchronous presentation of 2 unrelated sarcomas, extensive genomic analyses did not reveal any unifying somatic or germline mutations nor any apparent cancer predisposition. This case also highlights the potential role of utilizing plasma cell-free DNA for diagnosing tumors in locations where biopsy confers high morbidity.

publication date

  • January 5, 2017

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC5498269

Digital Object Identifier (DOI)

  • 10.1097/MPH.0000000000000754

PubMed ID

  • 28060130