Speed Limits for Nonvesicular Intracellular Sterol Transport Review uri icon

Overview

MeSH Major

  • Sterols

abstract

  • Sterol transport between the endoplasmic reticulum (ER) and plasma membrane (PM) occurs by nonvesicular mechanisms requiring sterol transport proteins (STPs). Here we examine the idea that transport is enhanced at membrane contact sites where the ER is closely apposed to the PM. We conclude that sterol desorption from the membrane, rather than STP-mediated diffusion, is rate limiting in the cellular context, so there is no apparent kinetic benefit to having STP-mediated sterol transfer occur at contact sites. Contact sites may instead compartmentalize lipid synthesis or transport machinery, providing opportunities for regulation.

publication date

  • February 2017

Research

keywords

  • Review

Identity

Language

  • eng

PubMed Central ID

  • PMC5272819

Digital Object Identifier (DOI)

  • 10.1016/j.tibs.2016.11.004

PubMed ID

  • 27956059

Additional Document Info

start page

  • 90

end page

  • 97

volume

  • 42

number

  • 2