Nuclear-specific AR-V7 Protein Localization is Necessary to Guide Treatment Selection in Metastatic Castration-resistant Prostate Cancer Academic Article uri icon

Overview

MeSH Major

  • Bone Neoplasms
  • Image Processing, Computer-Assisted
  • Prostatic Neoplasms

abstract

  • We analyzed outcomes for patients with metastatic castration-resistant prostate cancer on androgen receptor signaling inhibitors and standard chemotherapy. Patients with circulating tumor cells that had AR-V7 protein in the cellular nuclei were very likely to survive longer on taxane-based chemotherapy, and tests unable to distinguish where the protein is located in the cell are not as predictive of benefit.

publication date

  • January 2016

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC5401782

Digital Object Identifier (DOI)

  • 10.1016/j.eururo.2016.11.024

PubMed ID

  • 27979426

Additional Document Info