The Biology of Chronic Graft-versus-Host Disease: A Task Force Report from the National Institutes of Health Consensus Development Project on Criteria for Clinical Trials in Chronic Graft-versus-Host Disease Review uri icon

Overview

MeSH Major

  • Adaptive Immunity
  • Graft vs Host Disease
  • Hematopoietic Stem Cell Transplantation
  • T-Lymphocytes
  • Transplantation Immunology

abstract

  • Chronic graft-versus-host disease (GVHD) is the leading cause of late, nonrelapse mortality and disability in allogeneic hematopoietic cell transplantation recipients and a major obstacle to improving outcomes. The biology of chronic GVHD remains enigmatic, but understanding the underpinnings of the immunologic mechanisms responsible for the initiation and progression of disease is fundamental to developing effective prevention and treatment strategies. The goals of this task force review are as follows: This document is intended as a review of our understanding of chronic GVHD biology and therapies resulting from preclinical studies, and as a platform for developing innovative clinical strategies to prevent and treat chronic GVHD.

publication date

  • February 2017

Research

keywords

  • Review

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1016/j.bbmt.2016.09.023

PubMed ID

  • 27713092

Additional Document Info

start page

  • 211

end page

  • 234

volume

  • 23

number

  • 2