Excess Cardiovascular Risk in Women Relative to Men Referred for Coronary Angiography Is Associated with Severely Impaired Coronary Flow Reserve, Not Obstructive Disease
Coronary Artery Disease
Women referred for coronary angiography had a significantly lower burden of obstructive CAD in comparison with men but were not protected from CVD events. Excess cardiovascular risk in women was independently associated with impaired CFR, representing a hidden biological risk, and a phenotype less amenable to revascularization. Impaired CFR, particularly absent severely obstructive CAD, may represent a novel target for CVD risk reduction.