Myeloproliferative neoplasms, version 2.2017: Clinical Practice Guidelines in oncology Article Report uri icon

Overview

MeSH Major

  • Bone Marrow Cells
  • Primary Myelofibrosis

abstract

  • Myelofibrosis (MF), polycythemia vera (PV), and essential thrombocythemia (ET) are a group of heterogeneous disorders of the hematopoietic system collectively known as Philadelphia chromosome-negative myeloproliferative neoplasms (MPNs). The diagnosis and the management of patients with MPNs have evolved since the identification of mutations that activate the JAK pathway (JAK2, CALR, and MPL mutations) and the development of targeted therapies has resulted in significant improvements in disease-related symptoms and quality of life. This manuscript discusses the recommendations outlined in the NCCN Guidelines for the diagnostic workup of MPN (MF, PV, and ET), risk stratification, treatment, and supportive care strategies for the management of MF.

publication date

  • December 2016

Research

keywords

  • Report

Identity

PubMed ID

  • 27956542

Additional Document Info

start page

  • 1572

end page

  • 1611

volume

  • 14

number

  • 12