HIV-1 escape from a peptidic anchor inhibitor through stabilization of the envelope glycoprotein spike Academic Article uri icon

Overview

MeSH Major

  • HIV Envelope Protein gp120
  • HIV Envelope Protein gp41
  • HIV-1
  • Virus Internalization

abstract

  • Because of the rapid development of HIV-1 drug resistance, new drug targets need to be explored continuously. The fusion peptide of the envelope glycoprotein can be targeted by anchor inhibitors. Here we describe virus escape from the anchor inhibitor VIR165. Interestingly, some escape viruses became dependent on the inhibitor for cell entry. We show that the identified escape mutations stabilize the ground state of the envelope glycoprotein and should thus be useful in the design of stabilized envelope-based HIV vaccines.

publication date

  • January 2016

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC5110188

Digital Object Identifier (DOI)

  • 10.1128/JVI.01616-16

PubMed ID

  • 27654295

Additional Document Info

start page

  • 10587

end page

  • 10599

volume

  • 90

number

  • 23