Full expression of cardiomyopathy is partly dependent on B-cells: A pathway that involves cytokine activation, immunoglobulin deposition, and activation of apoptosis Academic Article uri icon

Overview

MeSH Major

  • Apoptosis
  • B-Lymphocytes
  • Cardiomyopathies
  • Cytokines
  • Heart Failure
  • Immunoglobulin G
  • Myocardium

abstract

  • The absence of B-cells in this model of HF resulted in less hypertrophy and collagen deposition, preservation of left ventricular function, and, in association with these changes, a reduction in expression of proinflammatory cytokines, immunoglobulin G deposition, and apoptosis in the myocardium. Taken together, these data suggest that B-cells play a contributory role in an angiotensin-II-induced HF model.

publication date

  • January 2016

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC4859365

Digital Object Identifier (DOI)

  • 10.1161/JAHA.115.002484

PubMed ID

  • 26769625

Additional Document Info

start page

  • 1

end page

  • 12

volume

  • 5

number

  • 1