Immunodynamics: A cancer immunotherapy trials network review of immune monitoring in immuno-oncology clinical trials Review uri icon

Overview

MeSH Major

  • Antineoplastic Agents
  • Neoplasms
  • Radiation-Sensitizing Agents
  • Taxoids

abstract

  • The efficacy of PD-1/PD-L1 targeted therapies in addition to anti-CTLA-4 solidifies immunotherapy as a modality to add to the anticancer arsenal. Despite raising the bar of clinical efficacy, immunologically targeted agents raise new challenges to conventional drug development paradigms by highlighting the limited relevance of assessing standard pharmacokinetics (PK) and pharmacodynamics (PD). Specifically, systemic and intratumoral immune effects have not consistently correlated with standard relationships between systemic dose, toxicity, and efficacy for cytotoxic therapies. Hence, PK and PD paradigms remain inadequate to guide the selection of doses and schedules, both starting and recommended Phase 2 for immunotherapies. The promise of harnessing the immune response against cancer must also be considered in light of unique and potentially serious toxicities. Refining immune endpoints to better inform clinical trial design represents a high priority challenge. The Cancer Immunotherapy Trials Network investigators review the immunodynamic effects of specific classes of immunotherapeutic agents to focus immune assessment modalities and sites, both systemic and importantly intratumoral, which are critical to the success of the rapidly growing field of immuno-oncology.

authors

publication date

  • March 15, 2016

Research

keywords

  • Review

Identity

Language

  • eng

PubMed Central ID

  • PMC4791805

Digital Object Identifier (DOI)

  • 10.1186/s40425-016-0118-0

PubMed ID

  • 26981245

Additional Document Info

start page

  • 15

volume

  • 4

number

  • 1