Modeling SF3B1 Mutations in Cancer: Advances, Challenges, and Opportunities Article uri icon

Overview

MeSH Major

  • Phosphoproteins
  • RNA Splicing Factors

abstract

  • In this issue of Cancer Cell, Obeng et al. identify the consequences of expressing the most common mutation in the spliceosomal gene SF3B1 on hematopoiesis. The knockin mouse model described represents a valuable tool to dissect the effects of SF3B1 mutations on transformation, splicing, and less well-characterized functions of SF3B1.

publication date

  • September 12, 2016

Research

keywords

  • Article

Identity

Digital Object Identifier (DOI)

  • 10.1016/j.ccell.2016.08.013

Additional Document Info

start page

  • 371

end page

  • 3

volume

  • 30

number

  • 3