Release of GP120 restraints leads to an entry-competent intermediate state of the HIV-1 envelope glycoproteins Academic Article uri icon


MeSH Major

  • HIV Envelope Protein gp120
  • HIV-1
  • Mutant Proteins
  • Virus Internalization


  • The envelope glycoproteins (Env) of HIV-1 mediate virus entry and are the sole targets of neutralizing antibodies. Understanding the way that Env promotes HIV-1 entry can expedite drug and vaccine development. By destabilizing Env, we found that it assumes an intermediate state that is functional and obligate for transitions to entry-competent conformations. Increased sampling of this state enhances the ability of HIV-1 to infect cells that express low levels of the CD4 receptor and allows the virus to evade neutralizing antibodies and small-molecule inhibitors. These findings provide new mechanistic insights into the function and inhibition of HIV-1 Env and will contribute to ongoing therapeutic and prevention efforts to combat HIV-1.

publication date

  • September 2016



  • Academic Article



  • eng

PubMed Central ID

  • PMC5080382

Digital Object Identifier (DOI)

  • 10.1128/mBio.01598-16

PubMed ID

  • 27795397

Additional Document Info


  • 7


  • 5