Sedation, Analgesia, and Paralysis during Mechanical Ventilation of Premature Infants
Hypnotics and Sedatives
Neuromuscular Blocking Agents
Administration of opioids and benzodiazepines in mechanically ventilated premature infants increased over time. Because infant characteristics were unchanged, site-specific differences in practice likely explain our observations. Increased administration over time is concerning given limited evidence of benefit and potential for harm.