Association of breast cancer risk in BRCA1 and BRCA2 mutation carriers with genetic variants showing differential allelic expression: identification of a modifier of breast cancer risk at locus 11q22.3 Academic Article uri icon

Overview

MeSH Major

  • Adaptor Proteins, Signal Transducing
  • Adenosine Triphosphatases
  • Colorectal Neoplasms
  • DNA Repair Enzymes
  • DNA-Binding Proteins
  • Nuclear Proteins

abstract

  • We identified 11q22.3 as a new modifier locus in BRCA1 carriers. Replication in larger studies using estrogen receptor (ER)-negative or triple-negative (i.e., ER-, progesterone receptor-, and HER2-negative) cases could therefore be helpful to confirm the association of this locus with breast cancer risk.

authors

publication date

  • January 2017

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC5222911

Digital Object Identifier (DOI)

  • 10.1007/s10549-016-4018-2

PubMed ID

  • 27796716

Additional Document Info

start page

  • 117

end page

  • 134

volume

  • 161

number

  • 1