Magnetic Resonance Venous Volume Measurements in Peripheral Artery Disease (from ELIMIT) Academic Article uri icon


MeSH Major

  • Femoral Vein
  • Leg
  • Magnetic Resonance Imaging
  • Peripheral Arterial Disease


  • The relation between the arterial and venous systems in patients with impaired lower extremity blood flow remains poorly described. The objective of this secondary analysis of the Effectiveness of Intensive Lipid Modification Medication in Preventing the Progression on Peripheral Artery Disease Trial was to determine the association between femoral vein (FV) volumes and measurements of peripheral artery disease. FV wall, lumen, and total volumes were quantified with fast spin-echo proton density-weighted magnetic resonance imaging scans in 79 patients with peripheral artery disease over 2 years. Reproducibility was excellent for FV total vessel (intraclass correlation coefficient 0.924, confidence interval 0.910 to 0.935) and lumen volumes (intraclass correlation coefficient 0.893, confidence interval 0.873 to 0.910). Baseline superficial femoral artery volumes were directly associated with FV wall (r = 0.46, p <0.0001), lumen (r = 0.42, p = 0.0001), and total volumes (r = 0.46, p <0.0001). The 2-year change in maximum walking time was inversely associated with the 24-month change in FV total volume (r = -0.45, p = 0.03). In conclusion, FV volumes can be measured reliably with fast spin-echo proton density-weighted magnetic resonance imaging, and baseline superficial femoral artery plaque burden is positively associated with FV volumes, whereas the 2-year change in FV volumes and leg function show an inverse relation.

publication date

  • November 2016



  • Academic Article



  • eng

PubMed Central ID

  • PMC5179037

Digital Object Identifier (DOI)

  • 10.1016/j.amjcard.2016.07.051

PubMed ID

  • 27670795

Additional Document Info

start page

  • 1399

end page

  • 1404


  • 118


  • 9