Characterization of a novel germline PALB2 duplication in a hereditary breast and ovarian cancer family Academic Article uri icon

Overview

MeSH Major

  • Breast Neoplasms
  • Germ-Line Mutation
  • Nuclear Proteins
  • Pancreatic Neoplasms
  • Tumor Suppressor Proteins

abstract

  • Our results indicate that the PALB2 exon 13 duplication is a pathogenic variant. The presence of the PALB2 duplication in the proband affected with high-grade serous ovarian cancer suggests that PALB2 might be associated with a predisposition to ovarian cancer.

publication date

  • December 2016

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC5646170

Digital Object Identifier (DOI)

  • 10.1007/s10549-016-4021-7

PubMed ID

  • 27757719

Additional Document Info

start page

  • 447

end page

  • 456

volume

  • 160

number

  • 3