Circulating plasma levels of MicroRNA-21 and MicroRNA-221 are potential diagnostic markers for primary intrahepatic cholangiocarcinoma Academic Article uri icon

Overview

MeSH Major

  • Adenocarcinoma
  • Green Fluorescent Proteins
  • Pancreatic Neoplasms
  • Peritoneal Neoplasms
  • Simplexvirus

abstract

  • Among the differentially expressed miRNAs in ICC, miR-21 and miR-221 are overexpressed and detectable in the circulation. Plasma expression levels of these miRNAs, particularly miR-21, accurately differentiates patients with ICC from healthy controls and could potentially serve as adjuncts in diagnosis. Prospective validation and comparison with other hepatobiliary malignancies is required to establish their potential role as diagnostic and prognostic biomarkers.

publication date

  • September 2016

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC5042503

Digital Object Identifier (DOI)

  • 10.1371/journal.pone.0163699

PubMed ID

  • 27685844

Additional Document Info

start page

  • e0163699

volume

  • 11

number

  • 9