Molecular and clinical effects of notch inhibition in glioma patients: A phase 0/I trial Academic Article uri icon

Overview

MeSH Major

  • Corpus Striatum
  • Embryonic Stem Cells
  • Graft Survival
  • Luminescent Measurements
  • Optics and Photonics
  • Stem Cell Transplantation

abstract

  • The addition of RO4929097 to temozolomide and radiotherapy was well tolerated; the drug has a variable blood-brain barrier penetration. Evidence of target modulation was observed, but recurrence occurred, associated with alterations in angiogenesis signaling pathways. Clin Cancer Res; 22(19); 4786-96. ©2016 AACR.

publication date

  • October 2016

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC5050072

Digital Object Identifier (DOI)

  • 10.1158/1078-0432.CCR-16-0048

PubMed ID

  • 27154916

Additional Document Info

start page

  • 4786

end page

  • 4796

volume

  • 22

number

  • 19