Strategy of Using Intratreatment Hypoxia Imaging to Selectively and Safely Guide Radiation Dose De-escalation Concurrent With Chemotherapy for Locoregionally Advanced Human Papillomavirus–Related Oropharyngeal Carcinoma Academic Article uri icon

Overview

MeSH Major

  • Carcinoma
  • Chemoradiotherapy
  • Misonidazole
  • Oropharyngeal Neoplasms
  • Radiotherapy, Image-Guided

abstract

  • Hypoxia is present in HPV(+) tumors but resolves within 1 week of treatment in 48% of cases either at the primary site and/or lymph node(s). Our 100% locoregional control rate suggests that intratreatment functional imaging used to selectively de-escalate node(s) to 60 Gy was confirmed safe using our stringent imaging criteria. Intratreatment functional imaging warrants further study to determine its ultimate role in de-escalation treatment strategies.

publication date

  • September 2016

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC5035649

Digital Object Identifier (DOI)

  • 10.1016/j.ijrobp.2016.04.027

PubMed ID

  • 27511842

Additional Document Info

start page

  • 9

end page

  • 17

volume

  • 96

number

  • 1