High Body Mass Index in Elderly Patients with DLBCL Treated with Rituximab-Containing Therapy Compensates for Negative Impact of Male Sex Academic Article Article uri icon

Overview

MeSH Major

  • Infant, Very Low Birth Weight
  • Leukemoid Reaction

abstract

  • High BMI was associated with a lower risk of disease progression or death than low or normal BMI, whereas male sex was associated with poor clinical outcomes, especially among elderly patients (age >60 years). Compared with elderly women, elderly men experienced worse PFS (3-year hazard ratio [HR], 1.5) and OS (3-year HR, 1.6), but these differences diminished with increases in BMI and BSA. In multivariable analysis, normal BMI compared with high BMI was independently associated with poor outcomes (3-year PFS HR, 1.5; OS HR, 1.6) after adjusting for sex. Notably, only 13% of elderly men had BMI less than 25 kg/m(2) and only 26% had BSA less than 2 m(2) CONCLUSIONS: Analysis of unselected patients with DLBCL treated with rituximab-containing chemotherapy confirmed an age-dependent disadvantage to male sex in treatment outcomes, but this effect is abrogated by higher levels of BMI and BSA in most North American men.

publication date

  • October 2016

Research

keywords

  • Academic Article

Identity

PubMed ID

  • 27697981

Additional Document Info

start page

  • 1274

end page

  • 1281

volume

  • 14

number

  • 10