Oxidative Stress and Huntington's Disease: The Good, the Bad, and the Ugly Review uri icon

Overview

MeSH Major

  • Huntington Disease
  • Oxidative Stress

abstract

  • Redox homeostasis is crucial for proper cellular functions, including receptor tyrosine kinase signaling, protein folding, and xenobiotic detoxification. Under basal conditions, there is a balance between oxidants and antioxidants. This balance facilitates the ability of oxidants, such as reactive oxygen species, to play critical regulatory functions through a direct modification of a small number of amino acids (e.g. cysteine) on signaling proteins. These signaling functions leverage tight spatial, amplitude, and temporal control of oxidant concentrations. However, when oxidants overwhelm the antioxidant capacity, they lead to a harmful condition of oxidative stress. Oxidative stress has long been held to be one of the key players in disease progression for Huntington's disease (HD). In this review, we will critically review this evidence, drawing some intermediate conclusions, and ultimately provide a framework for thinking about the role of oxidative stress in the pathophysiology of HD.

publication date

  • January 2016

Research

keywords

  • Review

Identity

Language

  • eng

PubMed Central ID

  • PMC5310831

Digital Object Identifier (DOI)

  • 10.3233/JHD-160205

PubMed ID

  • 27662334

Additional Document Info

start page

  • 217

end page

  • 237

volume

  • 5

number

  • 3