A Frameshift in CSF2RB Predominant Among Ashkenazi Jews Increases Risk for Crohn's Disease and Reduces Monocyte Signaling via GM-CSF Academic Article uri icon

Overview

MeSH Major

  • Crohn Disease
  • Cytokine Receptor Common beta Subunit
  • Frameshift Mutation
  • Granulocyte-Macrophage Colony-Stimulating Factor
  • Jews

abstract

  • In a genetic analysis of Ashkenazi Jewish individuals, we associated CD with a frameshift mutation in CSF2RB. Intestinal monocytes from carriers of this mutation had reduced responses to granulocyte-macrophage colony-stimulating factor, providing an additional mechanism for alterations to the innate immune response in individuals with CD.

authors

publication date

  • October 2016

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC5037012

Digital Object Identifier (DOI)

  • 10.1053/j.gastro.2016.06.045

PubMed ID

  • 27377463

Additional Document Info

start page

  • 710

end page

  • 723.e2

volume

  • 151

number

  • 4