Differential receptor tyrosine kinase PET Imaging for therapeutic guidance Academic Article uri icon

Overview

MeSH Major

  • Molecular Imaging
  • Neoplasms, Experimental
  • Positron-Emission Tomography
  • Receptor Protein-Tyrosine Kinases

abstract

  • Our imaging studies, using PET probes specific to EGFR and HER3, show that changes in RTK expression indicative of resistance to PI3K and AKT inhibitors can be seen within days of therapy initiation and are of sufficient magnitude as to allow reliable clinical interpretation. Noninvasive PET monitoring of these RTK feedback loops should help to rapidly assess resistance to PI3K and AKT inhibitors and guide selection of an appropriate combinatorial therapeutic regimen on an individual patient basis.

publication date

  • September 2016

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC5093919

Digital Object Identifier (DOI)

  • 10.2967/jnumed.115.169417

PubMed ID

  • 27081168

Additional Document Info

start page

  • 1413

end page

  • 9

volume

  • 57

number

  • 9