Non-lethal type VIII osteogenesis imperfecta has elevated bone matrix mineralization Academic Article uri icon

Overview

MeSH Major

  • Bone Density
  • Bone Matrix
  • Calcification, Physiologic
  • Membrane Glycoproteins
  • Osteogenesis Imperfecta
  • Proteoglycans

abstract

  • P3H1 is the unique enzyme responsible for collagen 3-hydroxylation in skin and bone. Bone from non-lethal type VIII OI children is similar to type VII, especially bone matrix hypermineralization, but it has distinctive features including extremely thin trabeculae, focal osteoid accumulation, and an increased proportion of low mineralized bone.

publication date

  • September 2016

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC5010570

Digital Object Identifier (DOI)

  • 10.1210/jc.2016-1334

PubMed ID

  • 27383115

Additional Document Info

start page

  • 3516

end page

  • 25

volume

  • 101

number

  • 9