Comparing Presenting Clinical Features in 48 Children With Microscopic Polyangiitis to 183 Children Who Have Granulomatosis With Polyangiitis (Wegener's): An ARChiVe Cohort Study
Academic Article
Overview
MeSH Major
Granulomatosis with Polyangiitis
Hemorrhage
Kidney Failure, Chronic
Lung Diseases
Microscopic Polyangiitis
Nephrotic Syndrome
Respiratory Insufficiency
abstract
Younger age at disease onset and, perhaps, both gastrointestinal manifestations and more severe kidney disease seem to characterize the clinical profile in children with MPA compared to those with GPA. Delay in diagnosis suggests that recognition of these systemic vasculitides is suboptimal. Compared with adults, initial treatment regimens in children were comparable, but the complete reversal of female-to-male disease prevalence ratios is a provocative finding.
