Resistance to imatinib in patients with chronic myelogenous leukemia and the splice variant BCR-ABL135INS Academic Article uri icon

Overview

MeSH Major

  • Leukemia, Myelogenous, Chronic, BCR-ABL Positive
  • Protein Kinase Inhibitors
  • RNA Splicing

abstract

  • The splice variant BCR-ABL1(35INS) is frequently found in patients who are resistant to imatinib. Mutations in the commonly mutated spliceosomal proteins do not contribute to this association.

publication date

  • October 2016

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC5625826

Digital Object Identifier (DOI)

  • 10.1016/j.leukres.2016.08.006

PubMed ID

  • 27658269

Additional Document Info

start page

  • 108

end page

  • 12

volume

  • 49