Quantitative susceptibility mapping and R2∗ measured changes during white matter lesion development in multiple sclerosis: Myelin breakdown, myelin debris degradation and removal, and iron accumulation Academic Article uri icon

Overview

MeSH Major

  • Cerebral Angiography
  • Cerebrovascular Circulation
  • Intracranial Aneurysm
  • Neuroimaging
  • Subarachnoid Hemorrhage
  • Tomography, X-Ray Computed

abstract

  • Early active MS lesions with nodular enhancement show R2* decrease but no quantitative susceptibility mapping change, reflecting myelin breakdown; late active lesions with peripheral enhancement show R2* decrease and quantitative susceptibility mapping increase in the lesion center, reflecting further degradation and removal of myelin debris; and early or late chronic nonenhancing lesions show both quantitative susceptibility mapping and R2* increase, reflecting iron accumulation.

publication date

  • September 2016

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC5018433

Digital Object Identifier (DOI)

  • 10.3174/ajnr.A4825

PubMed ID

  • 27256856

Additional Document Info

start page

  • 1629

end page

  • 35

volume

  • 37

number

  • 9