Cardiovascular Disorders and Epigenetics
Diabetes Mellitus, Type 2
Polymorphism, Single Nucleotide
© 2016 Elsevier Inc. All rights reserved.Cardiovascular disease is the leading cause of death worldwide. With the continuous increase in the prevalence and incidence of cardiovascular disorders, it has become imperative to understand more in depth their pathophysiology and search for novel biomarkers and therapies. Epigenetics refers to the heritable changes in gene expression that are not caused by the DNA sequence itself. Mounting evidence suggests that cardiovascular risk factors such as hypertension, diabetes, obesity, and smoking are associated with changes of epigenetic components. Additionally, these risk factors may trigger modifications within the epigenome, affecting the expression of several genes and inducing cardiac pathologies such as atherosclerotic disease, heart failure, and hypertrophic cardiomyopathy. Emerging experimental data are showing that epigenetic-modifying agents can reverse some pathological cardiovascular conditions. However, it is still unknown whether these approaches will be successfully translated into cardiovascular drugs.
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