Association between NRAS and BRAF mutational status and melanoma-specific survival among patients with higher-risk primary melanoma Academic Article uri icon

Overview

MeSH Major

  • Biomarkers, Tumor
  • GTP Phosphohydrolases
  • Melanoma
  • Membrane Proteins
  • Mutation
  • Proto-Oncogene Proteins B-raf
  • Skin Neoplasms

abstract

  • Lower TIL grade for NRAS+ melanoma suggests it has a more immunosuppressed microenvironment, which may affect its response to immunotherapies. The approximate 3-fold increased risk of death for higher-risk tumors harboring NRAS or BRAF mutations after adjusting for other prognostic factors compared with WT melanomas indicates that the prognostic implication of these mutations deserves further investigation, particularly in higher–AJCC stage primary melanomas.

authors

publication date

  • January 2015

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC4486299

Digital Object Identifier (DOI)

  • 10.1001/jamaoncol.2015.0493

PubMed ID

  • 26146664

Additional Document Info

start page

  • 359

end page

  • 68

volume

  • 1

number

  • 3