Nonenhancing Leptomeningeal Metastases: Imaging Characteristics and Potential Causative Factors Academic Article uri icon


MeSH Major

  • Decision Making
  • Radiosurgery
  • Spinal Neoplasms


  • The diagnosis of leptomeningeal metastasis (LM) has increased in frequency, as new therapies have lengthened the survival of patients with cancer. Early diagnosis and intervention help improve quality of life and prevent further neurological deterioration in LM. The detection of LM is often established by magnetic resonance imaging examinations, cerebrospinal fluid analysis, or both. We present a series of cases where LM was identified on fluid-attenuated inversion recovery or T2-weighted image but was nonenhancing on the traditionally more sensitive postcontrast T1-weighted sequences. Nonenhancing LM is unusual and not yet fully understood but should be considered in the appropriate clinical context and may become more common with increased utilization of antiangiogenic therapies.

publication date

  • January 2016



  • Academic Article



  • eng

PubMed Central ID

  • PMC4680901

Digital Object Identifier (DOI)

  • 10.1177/1941874415591702

PubMed ID

  • 26753054

Additional Document Info

start page

  • 24

end page

  • 8


  • 6


  • 1