Cranial Magnetic Resonance Imaging in Elderly American Indians: Design, Methods, and Implementation of the Cerebrovascular Disease and Its Consequences in American Indians Study Academic Article uri icon


MeSH Major

  • Adiposity
  • Blood Glucose
  • Cardiovascular Diseases
  • Glucose
  • Lipoproteins, HDL


  • The Cerebrovascular Disease and its Consequences in American Indians (CDCAI) Study recruited surviving members of a 20-year, longitudinal, population-based cohort of American Indians focused on cardiovascular disease, its risk factors, and its consequences. The goal of the CDCAI Study is to characterize the burden, risk factors, and manifestations of vascular brain injury identified on cranial MRI. The CDCAI Study investigators enrolled 1,033 participants aged 60 and older from 11 American Indian communities and tribes in the Northern Plains, Southern Plains, and Southwestern United States. In addition to cranial MRI performed according to standardized protocols, participants underwent extensive medical interview, clinical examination, neurocognitive testing, physical function evaluation, electrocardiogram, and provided blood and urine specimens. Participants also self-administered questionnaires covering demographics, quality of life, and medical history. This report describes the design, implementation, and some of the unique challenges of this study and data collection.

publication date

  • September 8, 2016



  • Academic Article



  • eng

PubMed Central ID

  • PMC5121036

Digital Object Identifier (DOI)

  • 10.1159/000443277

PubMed ID

  • 27603047

Additional Document Info

start page

  • 67

end page

  • 75