Sampling Hyperpolarized Molecules Utilizing a 1 Tesla Permanent Magnetic Field Academic Article uri icon


MeSH Major

  • Brain Neoplasms
  • Glioblastoma
  • Poly(ADP-ribose) Polymerases
  • Positron-Emission Tomography


  • Hyperpolarized magnetic resonance spectroscopy (HP MRS) using dynamic nuclear polarization (DNP) is a technique that has greatly enhanced the sensitivity of detecting (13)C nuclei. However, the HP MRS polarization decays in the liquid state according to the spin-lattice relaxation time (T1) of the nucleus. Sampling of the signal also destroys polarization, resulting in a limited temporal ability to observe biologically interesting reactions. In this study, we demonstrate that sampling hyperpolarized signals using a permanent magnet at 1 Tesla (1T) is a simple and cost-effective method to increase T1s without sacrificing signal-to-noise. Biologically-relevant information may be obtained with a permanent magnet using enzyme solutions and in whole cells. Of significance, our findings indicate that changes in pyruvate metabolism can also be quantified in a xenograft model at this field strength.

publication date

  • September 6, 2016



  • Academic Article



  • eng

PubMed Central ID

  • PMC5011774

Digital Object Identifier (DOI)

  • 10.1038/srep32846

PubMed ID

  • 27597137

Additional Document Info

start page

  • 32846


  • 6