Transient and chronic seizure-induced inflammation in human focal epilepsy Academic Article uri icon

Overview

MeSH Major

  • Encephalitis
  • Epilepsies, Partial

abstract

  • In animal models, inflammation is both a cause and consequence of seizures. Less is known about the role of inflammation in human epilepsy. We performed positron emission tomography (PET) using a radiotracer sensitive to brain inflammation in a patient with frontal epilepsy ~36 h after a seizure as well as during a seizure-free period. When statistically compared to a group of 12 matched controls, both of the patient's scans identified a frontal (supplementary motor area) region of increased inflammation corresponding to his clinically defined seizure focus, but the postseizure scan showed significantly greater inflammation intensity and spatial extent. These results provide new information about transient and chronic neuroinflammation in human epilepsy and may be relevant to understanding the process of epileptogenesis and guiding therapy.

publication date

  • September 2016

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC5266563

Digital Object Identifier (DOI)

  • 10.1111/epi.13457

PubMed ID

  • 27381590

Additional Document Info

start page

  • e191

end page

  • 4

volume

  • 57

number

  • 9