A proportion of primary squamous cell carcinomas of the parotid gland harbour high-risk human papillomavirus Academic Article uri icon

Overview

MeSH Major

  • Carcinoma, Squamous Cell
  • Head and Neck Neoplasms
  • Papillomavirus Infections
  • Parotid Neoplasms

abstract

  • Given the established aetiological role of HR-HPV in other head and neck squamous cell carcinomas, it is likely that HR-HPV represents an oncogenic driver in the pathogenesis of more than one-third of ParSCCs. The presence of HR-HPV in ParSCC may be coupled with alterations in the PTEN-PI3K pathway. Further studies on HR-HPV and the molecular characterization of a larger number of ParSCCs are needed to determine the clinical significance of these findings.

publication date

  • December 2016

Research

keywords

  • Academic Article

Identity

Language

  • eng

PubMed Central ID

  • PMC5115934

Digital Object Identifier (DOI)

  • 10.1111/his.13027

PubMed ID

  • 27374168

Additional Document Info

start page

  • 921

end page

  • 929

volume

  • 69

number

  • 6