Adult Neurogenesis in the Subventricular Zone and Migration to the Olfactory Bulb
Nucleic Acid Conformation
© 2015 John Wiley & Sons, Inc. All rights reserved.This chapter focuses on both neurogenesis in the subventricular zone (SVZ) and the migration of neuroblasts through the rostral migratory stream (RMS) in the adult mammalian brain. The SVZ in both the human fetus (22-24 weeks post-conception) and infant (less than 18 months), however, has large numbers of polysialylated-neural cell adhesion molecule (PSA-NCAM) expressing cells. The integration of adult-born interneurons into the pre-existing olfactory bulb (OB) circuitry begins when progenitors reach their final position in either the periglomerular or granule cell layer. Adult-generated periglomerular interneurons take up to 6 weeks from progenitor formation in the SVZ to develop mature dendritic arbors and spine densities. In the periglomerular layer, there are numerous phenotypic subsets based on distinct combinatorial expression patterns of neurotransmitters, neuroactive peptides, transmembrane receptors, and calcium binding proteins. Adult rodents maintain neurogenesis in the SVZ, but neurogenic output does progressively decline during aging.
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