Paper-Based 3D Culture for the Study of Cancer Cells in vitro Conference Paper uri icon

Overview

MeSH Major

  • Attitude of Health Personnel
  • Education, Medical, Graduate
  • Professional Competence
  • Social Media
  • Students, Medical

abstract

  • © 15CBMS-0001.This paper reports the latest results in the development of stackable and reconfigurable layers of paper as scaffolds for 3D cell culture of cancer cells. Specifically, tissue-like constructs are formed in vitro to recapitulate aspects of the tumor microenvironment, particularly gradients of oxygen. In this work, we demonstrate two new applications of this system: i) a novel 3D migration assay [2] and ii) a radiosensitivity study. We show that lung cancer cell lines of known differences in their metastatic potential in vivo, respond differently in this system in both their migration behavior and sensitivity to radiation.

publication date

  • January 2015

Research

keywords

  • Conference Paper

Additional Document Info

start page

  • 38

end page

  • 40