Cytotoxic chemotherapy in the treatment of advanced renal cell carcinoma in the era of targeted therapy Review uri icon

Overview

MeSH Major

  • Antineoplastic Agents
  • Apoptosis
  • Carcinoma, Renal Cell
  • Kidney Neoplasms
  • Molecular Targeted Therapy

abstract

  • The role of cytotoxic chemotherapy in the treatment for clear cell RCC remains poorly defined. Cytotoxic chemotherapy is considered a standard of care in patients with mRCC with predominantly sarcomatoid differentiation and collecting duct RCC variants (Motzer et al., 2014). Early trials combining chemotherapy with targeted therapies are generally well tolerated and show clinical activity. A better understanding of the biology of aggressive subsets of RCC and mechanisms of resistance will help elucidate the role of cytotoxic agents in the current treatment paradigm of RCC.

publication date

  • December 2015

Research

keywords

  • Review

Identity

Language

  • eng

Digital Object Identifier (DOI)

  • 10.1016/j.critrevonc.2015.08.007

PubMed ID

  • 26321263

Additional Document Info

start page

  • 518

end page

  • 26

volume

  • 96

number

  • 3