Genetic/familial high-risk assessment: Colorectal version 1.2016: Clinical practice guidelines in oncology Academic Article Article uri icon

Overview

MeSH Major

  • Common Cold
  • Tomography, X-Ray Computed

abstract

  • This is a focused update highlighting the most current NCCN Guidelines for diagnosis and management of Lynch syndrome. Lynch syndrome is the most common cause of hereditary colorectal cancer, usually resulting from a germline mutation in 1 of 4 DNA mismatch repair genes (MLH1, MSH2, MSH6, or PMS2), or deletions in the EPCAM promoter. Patients with Lynch syndrome are at an increased lifetime risk, compared with the general population, for colorectal cancer, endometrial cancer, and other cancers, including of the stomach and ovary. As of 2016, the panel recommends screening all patients with colorectal cancer for Lynch syndrome and provides recommendations for surveillance for early detection and prevention of Lynch syndrome-associated cancers.

publication date

  • August 2016

Research

keywords

  • Academic Article

Identity

PubMed ID

  • 27496117

Additional Document Info

start page

  • 1010

end page

  • 30

volume

  • 14

number

  • 8